护理干预对格林巴利综合征出现呼吸麻痹的临床价值

目的探讨护理干预对格林巴利综合征出现呼吸麻痹的临床疗效。方法选取本院2004年1月～2011年6月收治的格林巴利综合征出现呼吸麻痹的患者54例,随机分为两组,采用常规护理的患者27例为对照组,采用护理干预的患者27例为观察组,比较两组患者干预后的临床指标。结果观察组呼吸机参数平台压、呼气末正压均略低于对照组,差异均无统计学意义（P〉0.05）。观察组呼吸机参数吸气峰压明显低于对照组,观察组呼吸机参数气道平均压、潮气量、每分钟通气量均明显高于对照组,差异均有统计学意义（P〈0.05）。观察组pH值略高于对照组,差异无统计学意义（P〉0.05）。观察组中心静脉压明显低于对照组,观察组动脉血氧分压、氧合指数、肺顺应性均明显高于对照组,观察组总有效率明显高于对照组,差异均有统计学意义（P〈0.05）。结论对格林巴利综合征出现呼吸麻痹的患者进行有效的护理干预,可以降低呼吸机的使用条件,改善患者呼吸麻痹的临床症状,值得临床推广使用。     

Flotrac/VigileoTM监测剖宫产患者血流动力学参数的初步研究

目前,心输出量(CO)监测最常使用的金标准是热稀释法的肺动脉导管技术.现在一些创伤性小,可以避免肺动脉导管操作风险的技术也开始用于监测心输出量[1].其通过分析动脉波形估算心输出量和其他血流动力学指标,可连续监测[2].对剖宫产患者施行腰麻可能造成母体严重低血压,心输出量下降,胎盘血供减少[3].预防和纠正腰麻下剖宫产术中的血流动力学不稳定曾是研究焦点,但大多数研究均使用无创监测设备评价术中血流动力学的变化[4].本研究旨在使用Flotrac/VigileoTM系统监测腰麻下行择期剖宫产的健康孕妇的血流动力学变化.     

不同护理干预方法对剖宫产产后恢复的疗效对比

目的比较护理干预及传统护理方式对剖产后恢复的疗效。方法将185例剖宫产产妇随机分为两组,观察组(95例)采用护理干预模式,对照组(90例)采用传统护理方式,比较两组产妇术后疼痛分级,排气、进食、泌乳、拔管时间,以及乳房恢复情况。结果观察组术后疼痛0级例数明显多于对照组,术后疼痛3级例数明显少于对照组。观察组术后排气、进食、泌乳、拔管时间明显短于对照组,且术后泌乳不通畅、乳房胀痛及乳房有硬结的例数均显著少于对照组。结论较传统护理而言,对剖宫产产妇采用护理干预模式可有效减轻术后疼痛,缩短术后排气、进食、泌乳、拔管时间,降低乳房不适发生率。     

亲情式护理在前列腺手术患者康复中的积极作用

目的:探讨亲情式护理方式在前列腺手术患者康复中的作用,为该类疾病的临床护理提供经验参考。方法:选择我院泌尿外科施行前列腺手术患者217例,随机分为两组,其中对照组(105例)采取传统护理方式,观察组(112例)采取亲情式护理方式。对患者治疗过程中的并发症及康复效果进行分析,并对患者满意度进行调查。结果:继发性出血等术后并发症在观察组112例患者中出现13例(11.6%),而在对照组中出现22例(21.0%),两组比较差异显著(P<0.05)。结论:较之传统的护理方式,亲情式护理方式可明显减少前列腺手术患者术后并发症的发生率,对患者的康复起着积极作用。     

老年妇女绝经后阴道流血的原因分析与治疗对策探讨

目的探讨分析老年妇女绝经后阴道流血的原因及治疗方案。方法回顾分析2007年1月-2011年12月我院接收的211例绝经后阴道流血及血性白带为主要症状的女性患者,排除因妊娠引起流血的病例,对其余患者进行妇科检查、经阴或腹部B超检查、TCT检查及宫腔镜下病理活检。观察分析所有患者的阴道流血的病因及病变程度。结果依据本组患者的各项检查及病理报告可分为：生殖器官炎症125例,子宫肌瘤18例,恶性肿瘤53例,其他15例。结论绝经早期阴道流血多数患者由生殖器官良性病变引起的,但随着绝经时间的延长,恶性程度越高,针对病因选取恰当的治疗方式才是行之有效的方案。     

The Wasi Matrix Reasoning Subtest

Previous research reported that the WAIS-III Matrix Reasoning (MR) subtest was insensitive to the effects of traumatic brain injury (TBI), learning disability, and attention deficit hyperactivity disorder. This study was conducted to determine whether these findings generalize to the Wechsler Abbreviated Scale of Intelligence (WASI) MR subtest and to explore the subtest's sensitivity to other brain disorders. When 81 brain-damaged patients completed the WASI, the MR subtest was the highest score in the profile. For subgroups of TBI and Dementia, MR yielded the highest mean T-score. For patients with stroke, MR was the second highest mean. Subtest comparisons with estimated premorbid IQ suggested MR might show selective sensitivity. Results indicated no predictive validity for TBI, whereas MR was sensitive to the cognitive sequelae of stroke and dementia.     

Quantifying transient binding of ISWI chromatin remodelers in living cells by pixel-wise photobleaching profile evolution analysis

Interactions between nuclear proteins and chromatin frequently occur on the time scale of seconds and below. These transient binding events are important for the fast identification of target sites as concluded from our previous analysis of the human chromatin remodelers Snf2H and Snf2L from the imitation switch (ISWI) family. Both ATP-driven molecular motor proteins are able to translocate nucleosomes along the DNA and appear to exert this activity only on a small number of nucleosomes to which they bind more tightly. For mechanistic studies, one needs to distinguish such translocation reactions or other long-lived interactions associated with conformational changes and/or ATP hydrolysis from nonproductive chromatin sampling during target search. These processes can be separated by measuring the duration of nucleosome binding with subsecond time resolution. To reach this goal, we have developed a fluorescence bleaching technique termed pixel-wise photobleaching profile evolution analysis (3PEA). It exploits the inherent time structure of confocal microscopy images and yields millisecond resolution. 3PEA represents a generally applicable approach to quantitate transient chromatin interactions in the 2- to 500-ms time regime within only ∼1 s needed for a measurement. The green autofluorescent protein (GFP)-tagged Snf2H and Snf2L and the inactive Snf2L+13 splice variant were studied by 3PEA in comparison to the isolated GFP or red autofluorescent protein and a GFP pentamer. Our results reveal that the residence time for transient chromatin binding of Snf2H and Snf2L is <2 ms, and strongly support the view that ISWI-type remodelers are only rarely active in unperturbed cells during G1 phase.     

Crossed cerebellar diaschisis: insights into oxygen challenge MRI

Hyperoxia during T2*-weighted magnetic resonance imaging (oxygen challenge imaging (OCI)) causes T2*-weighted signal change that is dependent on cerebral blood volume (CBV) and oxygen extraction fraction (OEF). Crossed cerebellar diaschisis (CCD), where CBV is reduced but OEF is maintained, may be used to understand the relative contributions of OEF and CBV to OCI results. In subjects with large hemispheric strokes, OCI showed reduced signal change in the contralesional cerebellum (P=0.027, n=12). This was associated with reduced CBV in contralesional cerebellum (P=0.039, n=9). CCD may be a useful model to determine the relative contribution of CBV to signal change measured by OCI.     

Reducing salt; preventing stroke

Life expectancy is increasing and populations are ageing around the world. This presents a number of challenges; namely an increase in the global burden of chronic diseases. Stroke is one of the most common non‐communicable diseases (NCDs) in an ageing population and is the leading cause of death worldwide; the most modifiable risk factor for which, is raised blood pressure (BP). Salt reduction as a means to reduce BP and therefore, stroke, is proven to be effective and has been recognised as such at a global level. Salt reduction reaches entire populations and can therefore benefit everyone, regardless of, gender, age, economic status or ethnicity. Excess salt consumption is a worldwide problem and so all countries need to work together to reduce population salt intake levels to reduce the global burden of stroke and other NCD's, including heart disease and heart failure. Our goal (Consensus Action on Salt and Health and World Action on Salt and Health), in line with the World Health Organization‐recommended target, is to reduce worldwide salt intake to less than 5 g per person per day by 2025. In light of this, National and World Salt Awareness Week 2012 (26 March to 1 April) will focus on ‘Reducing salt, preventing stroke’.